听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览HUMAN BRAIN MAPPING期刊下所有文献
  • Generalizing age effects on brain structure and cognition: A two-study comparison approach.

    abstract::Normal aging is accompanied by an interindividually variable decline in cognitive abilities and brain structure. This variability, in combination with methodical differences and differences in sample characteristics across studies, pose a major challenge for generalizability of results from different studies. Therefor...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24524

    authors: Jockwitz C,Mérillat S,Liem F,Oschwald J,Amunts K,Caspers S,Jäncke L

    更新日期:2019-06-01 00:00:00

  • Private but not social information validity modulates social conformity bias.

    abstract::It is well established that human behaviors are susceptible to others' opinions. However, optimal decision theory mandates choices be made upon the estimated validities of different information sources and little is known about whether and how people could wean themselves off social conformity bias, especially when th...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24536

    authors: Li L,Li KK,Li J

    更新日期:2019-06-01 00:00:00

  • Trait Openness and serotonin 2A receptors in healthy volunteers: A positron emission tomography study.

    abstract::Recent research found lasting increases in personality trait Openness in healthy individuals and patients after administration of the serotonin 2A receptor (5-HT2A R) agonist psilocybin. However, no studies have investigated whether 5-HT2A R availability as imaged using positron emission tomography (PET) is associated...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24511

    authors: Stenbaek DS,Kristiansen S,Burmester D,Madsen MK,Frokjaer VG,Knudsen GM,Fisher PM

    更新日期:2019-05-01 00:00:00

  • Fronto-insular-parietal network engagement underlying arithmetic word problem solving.

    abstract::Mathematical word problems are ubiquitous and standard for teaching and evaluating generalization of mathematical knowledge for real-world contexts. It is therefore concerning that the neural mechanisms of word problem solving are not well understood, as these insights represent strong potential for improving educatio...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24502

    authors: Chang TT,Lung TC,Ng CT,Metcalfe AWS

    更新日期:2019-04-15 00:00:00

  • Does the insula contribute to emotion-related distortion of time? A neuropsychological approach.

    abstract::The literature points to a large distributed brain network involved in the estimation of time. Among these regions, the role of the insular cortex is still poorly understood. At the confluence of emotional, interoceptive, and environmental signals, this brain structure has been proposed to underlie awareness of the pa...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24460

    authors: Mella N,Bourgeois A,Perren F,Viaccoz A,Kliegel M,Picard F

    更新日期:2019-04-01 00:00:00

  • The inferior occipital gyrus is a major cortical source of the face-evoked N170: Evidence from simultaneous scalp and intracerebral human recordings.

    abstract::The sudden onset of a face image leads to a prominent face-selective response in human scalp electroencephalographic (EEG) recordings, peaking 170 ms after stimulus onset at occipito-temporal (OT) scalp sites: the N170 (or M170 in magnetoencephalography). According to a widely held view, the main cortical source of th...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24455

    authors: Jacques C,Jonas J,Maillard L,Colnat-Coulbois S,Koessler L,Rossion B

    更新日期:2019-04-01 00:00:00

  • Resting-state functional connectivity after concussion is associated with clinical recovery.

    abstract::There has been a recent call for longitudinal imaging studies to better characterize the time course of physiological recovery following sport-related concussion (SRC) and its relationship with clinical recovery. To address this, we evaluated changes to resting-state functional connectivity (rs-FC) of the whole-brain ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24440

    authors: Kaushal M,España LY,Nencka AS,Wang Y,Nelson LD,McCrea MA,Meier TB

    更新日期:2019-03-01 00:00:00

  • Characterizing hippocampal dynamics with MEG: A systematic review and evidence-based guidelines.

    abstract::The hippocampus, a hub of activity for a variety of important cognitive processes, is a target of increasing interest for researchers and clinicians. Magnetoencephalography (MEG) is an attractive technique for imaging spectro-temporal aspects of function, for example, neural oscillations and network timing, especially...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24445

    authors: Ruzich E,Crespo-García M,Dalal SS,Schneiderman JF

    更新日期:2019-03-01 00:00:00

  • I lie, why don't you: Neural mechanisms of individual differences in self-serving lying.

    abstract::People tend to lie in varying degrees. To advance our understanding of the underlying neural mechanisms of this heterogeneity, we investigated individual differences in self-serving lying. We performed a functional magnetic resonance imaging study in 37 participants and introduced a color-reporting game where lying ab...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24432

    authors: Yin L,Weber B

    更新日期:2019-03-01 00:00:00

  • Opposing patterns of neuronal variability in the sensorimotor network mediate cyclothymic and depressive temperaments.

    abstract::Affective temperaments have been described since the early 20th century and may play a central role in psychiatric illnesses, such as bipolar disorder (BD). However, the neuronal basis of temperament is still unclear. We investigated the relationship of temperament with neuronal variability in the resting state signal...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24453

    authors: Conio B,Magioncalda P,Martino M,Tumati S,Capobianco L,Escelsior A,Adavastro G,Russo D,Amore M,Inglese M,Northoff G

    更新日期:2019-03-01 00:00:00

  • Quantitative tract-based white matter heritability in 1- and 2-year-old twins.

    abstract::White matter (WM) microstructure, as determined by diffusion tensor imaging (DTI), is increasingly recognized as an important determinant of cognitive function and is also altered in neuropsychiatric disorders. Little is known about genetic and environmental influences on WM microstructure, especially in early childho...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24436

    authors: Lee SJ,Zhang J,Neale MC,Styner M,Zhu H,Gilmore JH

    更新日期:2019-03-01 00:00:00

  • Regional and network properties of white matter function in Parkinson's disease.

    abstract::Parkinson's disease (PD) is a neurodegenerative disorder with dysfunction in cortices as well as white matter (WM) tracts. While the changes to WM structure have been extensively investigated in PD, the nature of the functional changes to WM remains unknown. In this study, the regional activity and functional connecti...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24444

    authors: Ji GJ,Ren C,Li Y,Sun J,Liu T,Gao Y,Xue D,Shen L,Cheng W,Zhu C,Tian Y,Hu P,Chen X,Wang K

    更新日期:2019-03-01 00:00:00

  • Brain and soccer: Functional patterns of brain activity during the generation of creative moves in real soccer decision-making situations.

    abstract::This fMRI study investigated brain activity while soccer players were imagining creative moves in real soccer decision-making situations. After presenting brief video clips of a soccer scene, participants had to imagine themselves as the acting player and think either of a creative or obvious move that might lead to a...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24408

    authors: Fink A,Bay JU,Koschutnig K,Prettenthaler K,Rominger C,Benedek M,Papousek I,Weiss EM,Seidel A,Memmert D

    更新日期:2019-02-15 00:00:00

  • Sex differences in own and other body perception.

    abstract::Own body perception, and differentiating and comparing one's body to another person's body, are common cognitive functions that have relevance for self-identity and social interactions. In several psychiatric conditions, including anorexia nervosa, body dysmorphic disorder, gender dysphoria, and autism spectrum disord...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24388

    authors: Burke SM,Majid DSA,Manzouri AH,Moody T,Feusner JD,Savic I

    更新日期:2019-02-01 00:00:00

  • Vitamin D deficiency is associated with reduced hippocampal volume and disrupted structural connectivity in patients with mild cognitive impairment.

    abstract::Vitamin D deficiency may exacerbate adverse neurocognitive outcomes in the progression of diseases such as Parkinson's, Alzheimer's, and other dementias. Mild cognitive impairment (MCI) is prodromal for these neurocognitive disorders and neuroimaging studies suggest that, in the elderly, this cognitive impairment is a...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24380

    authors: Al-Amin M,Bradford D,Sullivan RKP,Kurniawan ND,Moon Y,Han SH,Zalesky A,Burne THJ

    更新日期:2019-02-01 00:00:00

  • Abnormal neural response to phonological working memory demands in persistent developmental stuttering.

    abstract::Persistent developmental stuttering is a neurological disorder that commonly manifests as a motor problem. Cognitive theories, however, hold that poorly developed cognitive skills are the origins of stuttering. Working memory (WM), a multicomponent cognitive system that mediates information maintenance and manipulatio...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24366

    authors: Yang Y,Jia F,Fox PT,Siok WT,Tan LH

    更新日期:2019-01-01 00:00:00

  • Alterations in intrinsic fronto-thalamo-parietal connectivity are associated with cognitive control deficits in psychotic disorders.

    abstract::Despite a growing number of reports about alterations in intrinsic/resting brain activity observed in patients with psychotic disorders, their relevance to well-established cognitive control deficits in this patient group is not well understood. Totally 88 clinically stabilized patients with a psychotic disorder and 5...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24362

    authors: Lencer R,Yao L,Reilly JL,Keedy SK,McDowell JE,Keshavan MS,Pearlson GD,Tamminga CA,Gershon ES,Clementz BA,Lui S,Sweeney JA

    更新日期:2019-01-01 00:00:00

  • Functional connectivity with cortical depth assessed by resting state fMRI of subregions of S1 in squirrel monkeys.

    abstract::Whereas resting state blood oxygenation-level dependent (BOLD) functional MRI has been widely used to assess functional connectivity between cortical regions, the laminar specificity of such measures is poorly understood. This study aims to determine: (a) whether the resting state functional connectivity (rsFC) betwee...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24375

    authors: Mishra A,Majumdar S,Wang F,Wilson GH 3rd,Gore JC,Chen LM

    更新日期:2019-01-01 00:00:00

  • Task-evoked functional connectivity does not explain functional connectivity differences between rest and task conditions.

    abstract::During complex tasks, patterns of functional connectivity differ from those in the resting state. However, what accounts for such differences remains unclear. Brain activity during a task reflects an unknown mixture of spontaneous and task-evoked activities. The difference in functional connectivity between a task sta...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24335

    authors: Lynch LK,Lu KH,Wen H,Zhang Y,Saykin AJ,Liu Z

    更新日期:2018-12-01 00:00:00

  • Disrupted interactions among the hippocampal, dorsal attention, and central-executive networks in amnestic mild cognitive impairment.

    abstract::Neuroimaging investigations consistently demonstrate that the neural processes involve complex interactions between the large-scale networks. Among those networks, the dorsal attention network (DAN) and the central-executive network (CEN) have been previously shown to exhibit anti-correlated activity with the default-...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24339

    authors: Chand GB,Hajjar I,Qiu D

    更新日期:2018-12-01 00:00:00

  • From simultaneous to synergistic MR-PET brain imaging: A review of hybrid MR-PET imaging methodologies.

    abstract::Simultaneous Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) scanning is a recent major development in biomedical imaging. The full integration of the PET detector ring and electronics within the MR system has been a technologically challenging design to develop but provides capacity for simult...

    journal_title:Human brain mapping

    pub_type: 杂志文章,评审

    doi:10.1002/hbm.24314

    authors: Chen Z,Jamadar SD,Li S,Sforazzini F,Baran J,Ferris N,Shah NJ,Egan GF

    更新日期:2018-12-01 00:00:00

  • Altered neural signatures of interoception in multiple sclerosis.

    abstract::Multiple sclerosis (MS) patients present several alterations related to sensing of bodily signals. However, no specific neurocognitive impairment has yet been proposed as a core deficit underlying such symptoms. We aimed to determine whether MS patients present changes in interoception-that is, the monitoring of auton...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24319

    authors: Salamone PC,Esteves S,Sinay VJ,García-Cordero I,Abrevaya S,Couto B,Adolfi F,Martorell M,Petroni A,Yoris A,Torquati K,Alifano F,Legaz A,Cassará FP,Bruno D,Kemp AH,Herrera E,García AM,Ibáñez A,Sedeño L

    更新日期:2018-12-01 00:00:00

  • Functional cerebral asymmetry analyses reveal how the control system implements its flexibility.

    abstract::The control system in human brain generally exerts the goal-directed regulation on a variety of mental processes. To deal with different control demands, these brain areas of the control system, especially the dorsolateral prefrontal cortex (DLPFC), may be flexibly recruited across different tasks. However, few studie...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24313

    authors: Chen Z,Zhao X,Fan J,Chen A

    更新日期:2018-12-01 00:00:00

  • Neural specialization of phonological and semantic processing in young children.

    abstract::This study aimed to examine early specialization of brain regions for phonological and semantic processing of spoken language in young children. Thirty-five typically developing children aged from 5 to 6 years performed auditory phonological (same sound judgment) and semantic (related meaning judgment) word-level task...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24274

    authors: Weiss Y,Cweigenberg HG,Booth JR

    更新日期:2018-11-01 00:00:00

  • Nonlinear neuroplasticity corresponding to sports experience: A voxel-based morphometry and resting-state functional connectivity study.

    abstract::We aimed to investigate the structural neuroplasticity associated with different levels of sports experience and its effect on the corresponding resting-state functional circuitry. We recruited 18 skilled baseball batters (SB), 19 intermediate baseball batters (IB), and 17 healthy controls (HC), and used magnetic reso...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24280

    authors: Chang CY,Chen YH,Yen NS

    更新日期:2018-11-01 00:00:00

  • Evidence for a general performance-monitoring system in the human brain.

    abstract::Adaptive behavior relies on the ability of the brain to form predictions and monitor action outcomes. In the human brain, the same system is thought to monitor action outcomes regardless of whether the information originates from internal (e.g., proprioceptive) and external (e.g., visual) sensory channels. Neural sign...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24273

    authors: Zubarev I,Parkkonen L

    更新日期:2018-11-01 00:00:00

  • Disrupted neural variability during propofol-induced sedation and unconsciousness.

    abstract::Variability quenching is a widespread neural phenomenon in which trial-to-trial variability (TTV) of neural activity is reduced by repeated presentations of a sensory stimulus. However, its neural mechanism and functional significance remain poorly understood. Recurrent network dynamics are suggested as a candidate me...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24304

    authors: Huang Z,Zhang J,Wu J,Liu X,Xu J,Zhang J,Qin P,Dai R,Yang Z,Mao Y,Hudetz AG,Northoff G

    更新日期:2018-11-01 00:00:00

  • Default-mode network dynamics are restricted during high speed discrimination in healthy aging: Associations with neurocognitive status and simulated driving behavior.

    abstract::Numerous daily tasks, including car driving, require fine visuospatial tuning. One such visuospatial ability, speed discrimination, declines with aging but its neural underpinnings remain unknown. In this study, we use fMRI to explore the effect of aging during a high speed discrimination task and its neural underpinn...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24240

    authors: Eudave L,Martínez M,Luis EO,Pastor MA

    更新日期:2018-11-01 00:00:00

  • Visual processing as a potential endophenotype in youths with attention-deficit/hyperactivity disorder: A sibling study design using the counting Stroop functional MRI.

    abstract::Deficits in inhibitory control and visual processing are common in youths with attention-deficit/hyperactivity disorder (ADHD), but little is known about endophenotypes for unaffected siblings of youths with ADHD. This study aimed to investigate the potential endophenotypes of brain activation and performance in inhib...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24214

    authors: Fan LY,Shang CY,Tseng WI,Gau SS,Chou TL

    更新日期:2018-10-01 00:00:00

  • Real-time strategy video game experience and structural connectivity - A diffusion tensor imaging study.

    abstract::Experienced video game players exhibit superior performance in visuospatial cognition when compared to non-players. However, very little is known about the relation between video game experience and structural brain plasticity. To address this issue, a direct comparison of the white matter brain structure in RTS (real...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24208

    authors: Kowalczyk N,Shi F,Magnuski M,Skorko M,Dobrowolski P,Kossowski B,Marchewka A,Bielecki M,Kossut M,Brzezicka A

    更新日期:2018-09-01 00:00:00

  • Spatio-temporal dynamics of resting-state brain networks improve single-subject prediction of schizophrenia diagnosis.

    abstract::Correlation in functional MRI activity between spatially separated brain regions can fluctuate dynamically when an individual is at rest. These dynamics are typically characterized temporally by measuring fluctuations in functional connectivity between brain regions that remain fixed in space over time. Here, dynamics...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24202

    authors: Kottaram A,Johnston L,Ganella E,Pantelis C,Kotagiri R,Zalesky A

    更新日期:2018-09-01 00:00:00

  • Accurate nonlinear mapping between MNI volumetric and FreeSurfer surface coordinate systems.

    abstract::The results of most neuroimaging studies are reported in volumetric (e.g., MNI152) or surface (e.g., fsaverage) coordinate systems. Accurate mappings between volumetric and surface coordinate systems can facilitate many applications, such as projecting fMRI group analyses from MNI152/Colin27 to fsaverage for visualiza...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24213

    authors: Wu J,Ngo GH,Greve D,Li J,He T,Fischl B,Eickhoff SB,Yeo BTT

    更新日期:2018-09-01 00:00:00

  • BrainMap VBM: An environment for structural meta-analysis.

    abstract::The BrainMap database is a community resource that curates peer-reviewed, coordinate-based human neuroimaging literature. By pairing the results of neuroimaging studies with their relevant meta-data, BrainMap facilitates coordinate-based meta-analysis (CBMA) of the neuroimaging literature en masse or at the level of e...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24078

    authors: Vanasse TJ,Fox PM,Barron DS,Robertson M,Eickhoff SB,Lancaster JL,Fox PT

    更新日期:2018-08-01 00:00:00

  • Individual differences in stop-related activity are inflated by the adaptive algorithm in the stop signal task.

    abstract::Research using the Stop Signal Task employing an adaptive algorithm to accommodate individual differences often report inferior performance on the task in individuals with ADHD, OCD, and substance use disorders compared to non-clinical controls. Furthermore, individuals with deficits in inhibitory control tend to show...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24075

    authors: D'Alberto N,Chaarani B,Orr CA,Spechler PA,Albaugh MD,Allgaier N,Wonnell A,Banaschewski T,Bokde ALW,Bromberg U,Büchel C,Quinlan EB,Conrod PJ,Desrivières S,Flor H,Fröhner JH,Frouin V,Gowland P,Heinz A,Itterman B,Mar

    更新日期:2018-08-01 00:00:00

  • Presurgical language fMRI: Clinical practices and patient outcomes in epilepsy surgical planning.

    abstract::The goal of this study was to document current clinical practice and report patient outcomes in presurgical language functional MRI (fMRI) for epilepsy surgery. Epilepsy surgical programs worldwide were surveyed as to the utility, implementation, and efficacy of language fMRI in the clinic; 82 programs responded. Resp...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24039

    authors: Benjamin CFA,Li AX,Blumenfeld H,Constable RT,Alkawadri R,Bickel S,Helmstaedter C,Meletti S,Bronen R,Warfield SK,Peters JM,Reutens D,Połczyńska M,Spencer DD,Hirsch LJ

    更新日期:2018-07-01 00:00:00

  • Spatial elongation of population receptive field profiles revealed by model-free fMRI back-projection.

    abstract::Estimates of visual field topographies in human visual cortex obtained through fMRI traveling wave techniques usually provide the parameters of population receptive field (pRF) location (polar angle, eccentricity) and receptive field size. These parameters are obtained by fitting the recorded data to a standard model ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24015

    authors: Merkel C,Hopf JM,Schoenfeld MA

    更新日期:2018-06-01 00:00:00

  • Statistical inference in brain graphs using threshold-free network-based statistics.

    abstract::The description of brain networks as graphs where nodes represent different brain regions and edges represent a measure of connectivity between a pair of nodes is an increasingly used approach in neuroimaging research. The development of powerful methods for edge-wise group-level statistical inference in brain graphs ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24007

    authors: Baggio HC,Abos A,Segura B,Campabadal A,Garcia-Diaz A,Uribe C,Compta Y,Marti MJ,Valldeoriola F,Junque C

    更新日期:2018-06-01 00:00:00

  • Disruption in neural phase synchrony is related to identification of inattentional deafness in real-world setting.

    abstract::Individuals often have reduced ability to hear alarms in real world situations (e.g., anesthesia monitoring, flying airplanes) when attention is focused on another task, sometimes with devastating consequences. This phenomenon is called inattentional deafness and usually occurs under critical high workload conditions....

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.24026

    authors: Callan DE,Gateau T,Durantin G,Gonthier N,Dehais F

    更新日期:2018-06-01 00:00:00

  • Spatiotemporal, metabolic, and therapeutic characterization of altered functional connectivity in major depressive disorder.

    abstract::Although imbalanced functional integration has been increasingly reported in major depressive disorder (MDD), there still lacks a general framework to characterize common characteristic and origin shared by the integrative disturbances. Here we examined spatial selectivity, temporal uniqueness, metabolic basis, and th...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23976

    authors: Sheng J,Shen Y,Qin Y,Zhang L,Jiang B,Li Y,Xu L,Chen W,Wang J

    更新日期:2018-05-01 00:00:00

  • Musical training induces functional and structural auditory-motor network plasticity in young adults.

    abstract::Playing music requires a strong coupling of perception and action mediated by multimodal integration of brain regions, which can be described as network connections measured by anatomical and functional correlations between regions. However, the structural and functional connectivities within and between the auditory ...

    journal_title:Human brain mapping

    pub_type: 杂志文章

    doi:10.1002/hbm.23989

    authors: Li Q,Wang X,Wang S,Xie Y,Li X,Xie Y,Li S

    更新日期:2018-05-01 00:00:00

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